Association of Keplerate-Type Polyoxometalate {Mo72Fe30} with Tetracycline: Nature of Binding Sites and Antimicrobial Action

The association process between the tetracycline (TC) antibiotic molecule and Keplerate-type nanocluster polyoxometalate (POM) {Mo72Fe30} was studied in aqueous solution. novel supramolecular ensemble {Mo72Fe30}@TC12.5 produced, its composition structure were revealed by means of elemental analysis (C, N, H) vibrational spectroscopy (IR Raman). Based on spectral data, POM structure’s integrity confirmed binding sites TC with Keplerate surface found. Due to thermogravimetric (TG) in-situ Raman during thermal destruction, we showed a significant change phase POM’s destruction products after TC. antibacterial activity obtained complex examined. experimental results allowed us note partial inhibition TC’s owing coordination FeIII centers, turn, which hinders participation via Mg2+ ribosomal subunits 30S bacteria.